Protherics PLC                         6 monthly Block Listing Return                         Unapproved Share Option SchemeLondon, UK; Brentwood, TN; 10 April 2008 - Protherics PLC ("Protherics" or the"Company"), the international biopharmaceutical company focused on critical careand cancer, in accordance with Listing Rule 3.5.6, notifies the followingdetails in respect of the block listing for its Unapproved Share Option Scheme:Name of applicant:                                         Protherics PLCName of scheme:                                            Protherics PLC Unapproved Share Option SchemePeriod of return:                           From:          9 October 2007         To:        8 April 2008Balance under scheme from previous return:                 3,126,947Plus: The amount by which the block scheme has been        Nilincreased, if the scheme has been increased since the dateof the last return:Less: Number of securities issued/allotted under scheme    Nilduring period:Equals: Balance under scheme not yet issued/allotted at    3,126,947end of periodNumber and class of securities originally listed and the   4,559,122 Ordinary Shares (date of admission: 8 April 2005)date of admissionName of contact:                                           Julie VickersTelephone number of contact:                               +44 (0) 1928 518010                                   |  Ends  |For further information please contact:ProthericsNick Staples, Director of Corporate Affairs                                     +44 (0) 7919  480510Julie Vickers, Company Secretary                                                +44 (0)1928 518010Financial Dynamics - press enquiriesLondon: Ben Atwell, Lara Mott                                                   +44 (0) 20 7831 3113New York: John Capodanno, Jonathan Birt                                         +1 212 850 5600Or visit  www.protherics.com                      This information is provided by RNS            The company news service from the London Stock Exchange