NOTIFICATION OF MAJOR INTERESTS IN SHARES1. Name of companySmith & Nephew plc2. Name of shareholder having a major interestNewton Investment Management Limited3. Please state whether notification indicates that it is in respect ofholding of the shareholder named in 2 above or in respect of anon-beneficial interest or in the case of an individual holder if it isa holding of that person's spouse or children under the age of 18Non-beneficial4. Name of the registered holder(s) and, if more than one holder, thenumber of shares held by each of them-------------------------------5. Number of shares / amount of stock acquired-------------------------------6. Percentage of issued class-------------------------------7. Number of shares / amount of stock disposed8. Percentage of issued class-------------------------------9. Class of securityOrdinary shares of US 20 cents10. Date of transaction24.06.0811. Date company informed25.06.0812. Total holding following this notification35,712,83213. Total percentage holding of issued class following thisnotification4.03%14. Any additional informationThis notification is further to the receipt of a TR1 Form in accordancewith the Disclosure and Transparency Rules.15. Name of contact and telephone number for queriesGemma Parsons - Assistant Company Secretary020 7960 222816. Name and signature of authorised company official responsible formaking this notificationGemma Parsons - Assistant Company SecretaryDate of notification26.06.08The FSA does not give any express or implied warranty as to theaccuracy of this document or material and does not accept any liabilityfor error or omission. The FSA is not liable for any damages(including, without limitation, damages for loss of business or loss ofprofits) arising in contract, tort or otherwise from the use of orinability to use this document, or any material contained in it, orfrom any action or decision taken as a result of using this document orany such material.                    This information is provided by RNS          The company news service from the London Stock ExchangeEND